Artificial tissue manufacturing and analysis technologies

We exploit tools from microfabrication, automation, chemistry, and synthetic biology to assemble 3D multicellular tissue structures that can be robustly manufactured and easily analyzed at scale. Using these models, we can analyze how the behaviour of different cell components in the tissue contributes to tissue function and dysfunction.

Relevant publications

  • An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues. Li NT, Wu NC, Cao R, Cadavid JL, Latour S, Lu X, Zhu Y, Mijalkovic M, Roozitalab R, Landon-Brace N, Notta F, McGuigan AP. Biomaterials. 2022 Dec;291:121883. doi: 10.1016/j.biomaterials.2022.121883.
  • An Automation Workflow for High-Throughput Manufacturing and Analysis of Scaffold-Supported 3D Tissue Arrays. Cao R, Li NT, Latour S, Cadavid JL, Tan CM, Forman A, Jackson HW, McGuigan AP. Adv Healthc Mater. 2023 Jul;12(19):e2202422. doi: 10.1002/adhm.202202422.
  • 3D microgels to quantify tumor cell properties and therapy response dynamics. Wu NC, Cadavid JL, Tan X, Latour S, Scaini S, Makhijani P, McGaha TL, Ailles L, McGuigan AP. Biomaterials. 2022 Apr;283:121417. doi: 10.1016/j.biomaterials.2022.121417. Epub 2022 Feb 16.PMID: 35231786
  • Gels for Live Analysis of Compartmentalized Environments (GLAnCE): A tissue model to probe tumour phenotypes at tumour-stroma interfaces. D’Arcangelo E, Wu NC, Chen T, Shahaj A, Cadavid JL, Huang L, Ailles L, McGuigan AP. Biomaterials. 2020 Jan;228:119572. doi: 10.1016/j.biomaterials.2019.119572. Epub 2019 Oct 23. PMID: 31683122
  • Development of a bioprinting approach for automated manufacturing of multi-cell type biocomposite TRACER strips using contact capillary-wicking. Li NT, Rodenhizer D, Mou J, Shahaj A, Samardzic K, McGuigan AP. Biofabrication. 2019 Oct 21;12(1):015001. doi: 10.1088/1758-5090/ab47e8. PMID: 31553953
  • A three-dimensional engineered heterogeneous tumor model for assessing cellular environment and response. Rodenhizer D, Dean T, Xu B, Cojocari D, McGuigan AP. Nat Protoc. 2018 Sep;13(9):1917-1957. doi: 10.1038/s41596-018-0022-9. PMID: 30190554
  • A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients. Rodenhizer D, Gaude E, Cojocari D, Mahadevan R, Frezza C, Wouters BG, McGuigan AP.Nat Mater. 2016 Feb;15(2):227-34. doi: 10.1038/nmat4482. Epub 2015 Nov 23.PMID: 26595121
  • Davoudi S, Xu B, Jacques E, Cadavid JL, McFee M, Chin C-Y, Meysami A, Ebrahimi M, Bakooshli MA, Tung K, Ahn H, Ginsberg HJ, McGuigan AP, Gilbert PM (Co-corresponding author) MEndR: An In Vitro Functional Assay to Predict In Vivo Muscle Stem Cell-Mediated Repair, Adv. Func. Mater., 2022, 32 (2), 2106548
  • Landon-Brace N, Cadavid JL, Latour S, Co IL, Rodenhizer D, Li NT, Wu NC, Bugbee E, Chebotarev A, Zhang J, Wouters BG, McGuigan AP (Corresponding author), An Engineered Patient-Derived Tumor Organoid Model That Can Be Disassembled to Study Cellular Responses in a Graded 3D Microenvironment, Adv. Funct. Mater., 2021, 31 (41), 2105349
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