For a complete list of publications from the McGuigan lab, please visit the pubmed page


  • Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3D in vitro tissue models of disease. Cadavid JL, Li NT, McGuigan AP. Biophys Rev (Melville). 2024 Apr 10;5(2):021301. doi: 10.1063/5.0179125.
  • Design Parameters for a Mass Cytometry Detectable HaloTag Ligand.Potter N, Latour S, Wong ECN, Winnik MA, Jackson HW, McGuigan AP, Nitz M.Bioconjug Chem. 2024 Jan 17;35(1):80-91. doi: 10.1021/acs.bioconjchem.3c00434.


  • Characterization of an N-Allylglyoxylamide-Based Bioorthogonal Nitrone Trap. Lee D, Latour S, Emblem M, Clark HJ, Santos JT, Jang J, McGuigan AP, Nitz M.Bioconjug Chem. 2023 Dec 20;34(12):2358-2365. doi: 10.1021/acs.bioconjchem.3c00463.
  • Exploring New Dimensions of Tumor Heterogeneity: The Application of Single Cell Analysis to Organoid-Based 3D In Vitro Models. Landon-Brace N, Li NT, McGuigan AP. Adv Healthc Mater. 2023 Oct;12(26):e2300903. doi: 10.1002/adhm.202300903.
  • An Automation Workflow for High-Throughput Manufacturing and Analysis of Scaffold-Supported 3D Tissue Arrays. Cao R, Li NT, Latour S, Cadavid JL, Tan CM, Forman A, Jackson HW, McGuigan AP. Adv Healthc Mater. 2023 Jul;12(19):e2202422. doi: 10.1002/adhm.202202422.
  • An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues. Li NT, Wu NC, Cao R, Cadavid JL, Latour S, Lu X, Zhu Y, Mijalkovic M, Roozitalab R, Landon-Brace N, Notta F, McGuigan AP. Biomaterials. 2022 Dec;291:121883. doi: 10.1016/j.biomaterials.2022.121883.
  • An Engineered Paper-Based 3D Coculture Model of Pancreatic Cancer to Study the Impact of Tissue Architecture and Microenvironmental Gradients on Cell Phenotype. Cadavid JL, Latour S, Nowlan F, Co IL, Landon-Brace N, Wouters BG, Grünwald BT, Nitz M, Jackson HW, McGuigan AP. Adv Healthc Mater. 2023 Jun;12(14):e2201846. doi: 10.1002/adhm.202201846.


  • MEndR: An In Vitro Functional Assay to Predict In Vivo Muscle Stem Cell-Mediated Repair, Davoudi S, Xu B, Jacques E, Cadavid JL, McFee M, Chin C-Y, Meysami A, Ebrahimi M, Bakooshli MA, Tung K, Ahn H, Ginsberg HJ, McGuigan AP, Gilbert PM  Adv. Func. Mater., 2022, 32 (2), 2106548
  • A three-dimensional human adipocyte model of fatty acid-induced obesity.Pieters VM, Rjaibi ST, Singh K, Li NT, Khan ST, Nunes SS, Dal Cin A, Gilbert PM, McGuigan AP. Biofabrication. 2022 Aug 19;14(4). doi: 10.1088/1758-5090/ac84b1.
  • REVOLVER: A low-cost automated protein purifier based on parallel preparative gravity column workflows. Diep P, Cadavid JL, Yakunin AF, McGuigan AP, Mahadevan R. HardwareX. 2022 Mar 11;11:e00291. doi: 10.1016/j.ohx.2022.e00291.
  • Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids. Prince E, Cruickshank J, Ba-Alawi W, Hodgson K, Haight J, Tobin C, Wakeman A, Avoulov A, Topolskaia V, Elliott MJ, McGuigan AP, Berman HK, Haibe-Kains B, Cescon DW, Kumacheva E. Nat Commun. 2022 Mar 18;13(1):1466. doi: 10.1038/s41467-022-28788-6.
  • 3D microgels to quantify tumor cell properties and therapy response dynamics.Wu NC, Cadavid JL, Tan X, Latour S, Scaini S, Makhijani P, McGaha TL, Ailles L, McGuigan AP. Biomaterials. 2022 Apr;283:121417. doi: 10.1016/j.biomaterials.2022.121417.
  • Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity.Hezaveh K, Shinde RS, Klötgen A, Halaby MJ, Lamorte S, Ciudad MT, Quevedo R, Neufeld L, Liu ZQ, Jin R, Grünwald BT, Foerster EG, Chaharlangi D, Guo M, Makhijani P, Zhang X, Pugh TJ, Pinto DM, Co IL, McGuigan AP, Jang GH, Khokha R, Ohashi PS, O’Kane GM, Gallinger S, Navarre WW, Maughan H, Philpott DJ, Brooks DG, McGaha TL. Immunity. 2022 Feb 8;55(2):324-340.e8. doi: 10.1016/j.immuni.2022.01.006.
  • Planar organization of airway epithelial cell morphology using hydrogel grooves during ciliogenesis fails to induce ciliary alignment. Varma R, Poon J, Liao Z, Aitchison JS, Waddell TK, Karoubi G, McGuigan AP. Biomater Sci. 2022 Jan 18;10(2):396-409. doi: 10.1039/d1bm01327k.
  • Microfluidic Arrays of Breast Tumor Spheroids for Drug Screening and Personalized Cancer Therapies. Prince E, Kheiri S, Wang Y, Xu F, Cruickshank J, Topolskaia V, Tao H, Young EWK, McGuigan AP, Cescon DW, Kumacheva E. Adv Healthc Mater. 2022 Jan;11(1):e2101085. doi: 10.1002/adhm.202101085.


  • Guided Self-Assembly of ES-Derived Lung Progenitors into Biomimetic Tube Structures That Impact Cell Differentiation. Soleas JP, Huang L, D’Arcangelo E, Nostro MC, Waddell TK, McGuigan AP, Karoubi G. Bioengineering (Basel). 2021 Dec 10;8(12):209. doi: 10.3390/bioengineering8120209.
  • An Engineered Patient-Derived Tumor Organoid Model That Can Be Disassembled to Study Cellular Responses in a Graded 3D Microenvironment, Landon-Brace N, Cadavid JL, Latour S, Co IL, Rodenhizer D, Li NT, Wu NC, Bugbee E, Chebotarev A, Zhang J, Wouters BG, McGuigan AP, Adv. Funct. Mater., 2021, 31 (41), 2105349
  • Gelatin-Hyaluronan Click-Crosslinked Cryogels Elucidate Human Macrophage Invasion Behavior. Bahlmann L. C, Baker, A. E. G, Xue C, Liu S, Meier-Merziger M, Karakas D, Zhu L, Co I, Zhao S, Chin A, McGuigan A, Kuruvilla J, Laister R. C, Shoichet M. S. Adv. Funct. Mater. 2021 Jul; doi: 10.1002/adfm.202008400
  • Application of CRISPR screens to investigate mammalian cell competition. Paraskevopoulos M, McGuigan AP. Brief Funct Genomics. 2021 Jun; doi: 10.1093/bfgp/elab020
  • Easy and robust micropatterning using fibrinogen anchors. Latour S, McGuigan AP. J Cell Biol. 2021 Feb; doi: 10.1083/jcb.202012105
  • Applications of Omics Technologies for 3D In Vitro Disease Models. Pieters V, Co I, Wu N, McGuigan AP. Tissue Engineering Part C. 2021 Jan; doi: 10.1089/ten.TEC.2020.0300


  • Matrix Stiffness-Regulated Growth of Breast Tumor Spheroids and Their Response to Chemotherapy. Li Y, Khuu N, Prince E, Tao H, Zhang N, Chen Z, Gevorkian A, McGuigan AP, Kumacheva E. Biomacromolecules. 2020 Nov; doi: 10.1021/acs.biomac.0c01287
  • Assembly of lung progenitors into developmentally-inspired geometry drives differentiation via cellular tension. Soleas JP, D’Arcangelo E, Huang L, Karoubi G, Nostro MC, McGuigan AP, Waddell TK. Biomaterials. 2020 Sept; doi: 10.1016/j.biomaterials.2020.120128
  • Tissue-engineered 3D cancer microenvironment for screening therapeutics. Materials Today. Li NT, Co I, Landon-Brace N, Latour S, McGuigan AP. 2020 Sept; doi: 10.1016/b978-0-12-818128-7.00019-8
  • Current strategies and opportunities to manufacture cells for modeling human lungs.Varma R, Soleas JP, Waddell TK, Karoubi G, McGuigan AP. Advanced Drug Delivery Reviews. 2020 Aug; doi: 10.1016/j.addr.2020.08.005
  • TRACER culture invasion assay to probe the impact of cancer associated fibroblasts on head and neck squamous cell carcinoma cell invasiveness. Dean T, Li NT, Cadavid JL, Ailles L, McGuigan AP. Biomaterials Science. 2020 June; doi: 10.1039/c9bm02017a
  • The life cycle of cancer-associated fibroblasts within the tumour stroma and its importance in disease outcome. D’Arcangelo E, Wu NC, Cadavid JL, McGuigan AP. British Journal of Cancer. 2020 January; doi: 10.1038/s41416-019-0705-1


  • Gels for Live Analysis of Compartmentalized Environments (GLAnCE): A tissue model to probe tumour phenotypes at tumour-stroma interfaces. D’Arcangelo E, Wu NC, Chen T, Shahaj A, Cadavid JL, Huang L, Ailles L, McGuigan AP. Biomaterials. 2019 Oct; doi: 10.1016/j.biomaterials.2019.119572
  • Development of a bioprinting approach for automated manufacturing of multi-cell type biocomposite TRACER strips using contact capillary-wicking. Li NT, Rodenhizer D, Mou J, Shahaj A, Samardzic K, McGuigan AP. Biofabrication, 2019 Oct; doi: 10.1088/1758-5090/ab47e8
  • Local cell coordination does not alter individual cell migration during collective migration but does impact cellular exchange events. Slater B, Ng E, McGuigan AP. Integrative Biology. 2019 April; doi: 10.1093/intbio/zyz015


  • A three-dimensional engineered heterogeneous tumor model for assessing cellular environment and response. Rodenhizer D, Dean T, Xu B, Cojocari D, McGuigan AP. Nature Protocols. 2018 Sept; doi: 10.1038/s41596-018-0022-9
  • A TRACER 3D Co-Culture tumour model for head and neck cancer. Young M, Rodenhizer D, Dean T, D’Arcangelo E, Xu B, Ailles L, McGuigan AP. Biomaterials. 2018 May; doi: 10.1016/j.biomaterials.2018.01.038
  • Design of biomimetic substrates for long-term maintenance of alveolar epithelial cells. Poon JCH, Liao Z, Suzuki T, Carleton MM, Soleas JP, Aitchison JS, Karoubi G, Mcguigan AP, Waddell TK. Biomater Sci. 2018 Jan; doi: 10.1039/c7bm00647k
  • The Current Landscape of 3D In Vitro Tumor Models: What Cancer Hallmarks Are Accessible for Drug Discovery?. Rodenhizer D, Dean T, D’Arcangelo E, McGuigan AP, Adv. Healthcare Mater. 2018 Jan; doi: 10.1002/adhm.201701174


  • Modulation of cellular polarization and migration by ephrin/Eph signal-mediated boundary formation., Javaherian S, D’Arcangelo E, Slater B, Londono C, Xu B, McGuigan AP., Integr Biol (Camb). 2017 Nov; 9(12): 934-946. doi: 10.1039/C7IB00176B.


  • Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization., Xiao Y, Reis LA, Feric N, Knee EJ, Gu J, Cao S, Laschinger C, Londono C, Antolovich J, McGuigan AP, Radisic M., Proc Natl Acad Sci U S A. 2016 Sep 19. pii: 201612277.
  • Patterning cellular compartments within TRACER cultures using sacrificial gelatin printing., Xu B, Rodenhizer D, Lakhani S, Zhang X, Soleas JP, Ailles L, McGuigan AP., Biofabrication. 2016 Sep 15;8(3):035018. doi: 10.1088/1758-5090/8/3/035018.
  • Tissue Patterning: Translating Design Principles from In Vivo to In Vitro., McGuigan AP, Javaherian S., Annu Rev Biomed Eng. 2016 Jul 11;18:1-24. doi: 10.1146/annurev-bioeng-083115-032943.
  • A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients., Rodenhizer D, Gaude E, Cojocari D, Mahadevan R, Frezza C, Wouters BG, McGuigan AP., Nat Mater. 2016 Feb;15(2):227-34. doi: 10.1038/nmat4482.


  • Topographically grooved gel inserts for aligning epithelial cells during air-liquid-interface culture., Soleas JP, Waddell TK, McGuigan AP., Biomater Sci. 2015 Jan;3(1):121-33. doi: 10.1039/c4bm00237g.
  • An in vitro model of tissue boundary formation for dissecting the contribution of different boundary forming mechanisms., Javaherian S, D’Arcangelo E, Slater B, Zulueta-Coarasa T, Fernandez-Gonzalez R, McGuigan AP., Integr Biol (Camb). 2015 Mar;7(3):298-312. doi: 10.1039/c4ib00272e.
  • Micropatterning strategies to engineer controlled cell and tissue architecture in vitro., D’Arcangelo E, McGuigan AP., Biotechniques. 2015 Jan 1;58(1):13-23. doi: 10.2144/000114245.


  • A microfluidic device to apply shear stresses to polarizing ciliated airway epithelium using air flow., Trieu D, Waddell TK, McGuigan AP., Biomicrofluidics. 2014 Nov 14;8(6):064104. doi: 10.1063/1.4901930.
  • A microgroove patterned multiwell cell culture plate for high-throughput studies of cell alignment., Lücker PB, Javaherian S, Soleas JP, Halverson D, Zandstra PW, McGuigan AP., Biotechnol Bioeng. 2014 Dec;111(12):2537-48. doi: 10.1002/bit.25298.
  • Multiwell plate tools for controlling cellular alignment with grooved topography., Londono C, Soleas J, Lücker PB, Sathananthan S, Aitchison JS, McGuigan AP., Methods Mol Biol. 2014;1202:37-55. doi: 10.1007/7651_2014_76.
  • Micropatterning cells on permeable membrane filters., Javaherian S, Paz AC, McGuigan AP., Methods Cell Biol. 2014;121:171-89. doi: 10.1016/B978-0-12-800281-0.00012-9.
  • Nonautonomous contact guidance signaling during collective cell migration., Londono C, Loureiro MJ, Slater B, Lücker PB, Soleas J, Sathananthan S, Aitchison JS, Kabla AJ, McGuigan AP., Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1807-12. doi: 10.1073/pnas.1321852111.
  • Challenges and opportunities for tissue-engineering polarized epithelium., Paz AC, Soleas J, Poon JC, Trieu D, Waddell TK, McGuigan AP., Tissue Eng Part B Rev. 2014 Feb;20(1):56-72. doi: 10.1089/ten.TEB.2013.0144.


  • A simple and rapid method for generating patterned co-cultures with stable interfaces., Javaherian S, Li KJ, McGuigan AP., Biotechniques. 2013 Jul;55(1):21-6. doi: 10.2144/000114051.
  • An algorithm to quantify correlated collective cell migration behavior., Slater B, Londono C, McGuigan AP., Biotechniques. 2013 Feb;54(2):87-92. doi: 10.2144/000113990.
  • Design principles for generating robust gene expression patterns in dynamic engineered tissues., Javaherian S, Anesiadis N, Mahadevan R, McGuigan AP., Integr Biol (Camb). 2013 Mar;5(3):578-89. doi: 10.1039/c3ib20274g.


  • Paz, A.C., Javaherian, S., McGuigan, A.P., Micropatterning co-cultured epithelial cell sheets on filter insert substrates, Journal of Epithelial Biology and Pharmacology, 2012, 5, 77-85
  • Soleas J, Paz AC, Marcus P, McGuigan, A.P., Waddell TK. Engineering tracheal epithelium. Journal of Biomedicine and Biotechnology, 2012, Article ID 982971


  • Tools for micropatterning epithelial cells into microcolonies on transwell filter substrates., Paz AC, Javaherian S, McGuigan AP., Lab Chip. 2011 Oct 21;11(20):3440-8. doi: 10.1039/c1lc20506d.
  • A fast and accessible methodology for micro-patterning cells on standard culture substrates using Parafilm™ inserts., Javaherian S, O’Donnell KA, McGuigan AP., PLoS One. 2011;6(6):e20909. doi: 10.1371/journal.pone.0020909.


  • Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans., Hulme SE, Shevkoplyas SS, McGuigan AP, Apfeld J, Fontana W, Whitesides GM., Lab Chip. 2010 Mar 7;10(5):589-97.
  • Cell encapsulation in sub-mm sized gel modules using replica molding., McGuigan AP, Bruzewicz DA, Glavan A, Butte MJ, Whitesides GM., PLoS One. 2008 May 21;3(5):e2258
  • Fabrication of a modular tissue construct in a microfluidic chip., Bruzewicz DA, McGuigan AP, Whitesides GM., Lab Chip. 2008 May;8(5):663-71.
  • The thrombogenicity of human umbilical vein endothelial cell seeded collagen modules., McGuigan AP, Sefton MV., Biomaterials. 2008 Jun;29(16):2453-63
  • Modular tissue engineering: fabrication of a gelatin-based construct.,  McGuigan AP, Sefton MV., J Tissue Eng Regen Med. 2007 Mar-Apr;1(2):136-45.
  • Design and fabrication of sub-mm-sized modules containing encapsulated cells for modular tissue engineering., McGuigan AP, Sefton MV., Tissue Eng. 2007 May;13(5):1069-78.
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