Tumour Microenvironment Engineering
Tumour Microenvironment Engineering Cancer drug discovery could significantly benefit from tissue mimetic platforms: the architecture of solid tumours is complex and heterogeneous, and current in vitro systems do not generate predictive data. For example, cellular metabolism is highly influenced by the local microenvironment, yet tumour cell metabolism is generally assessed ... Read More
Tissue Patterning Approaches
Tissue Patterning Approaches Recapitulating the architecture of native tissue is currently a significant challenge impeding the development of physiologically relevant in vitro mimetic systems. Instructing appropriate organization is especially challenging for tissues that feature organization of multiple cellular components into complex structural units. Traditionally, tissue engineers have directed cells into ... Read More
Collective Cell Migration
Collective Cell Migration Tissue self-assembly and repair requires three key elements: specification of cellular scale organization (e.g. cytoskeletal configuration and cell shape), specification of tissue scale organization (e.g.boundaries between different component phases), and specification of cell fates/phenotype. All of these elements are inter-related and must evolve with coordinated dynamics as self-organization proceeds. In ... Read More